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Trends Endocrinol Metab. 2014 Oct;25(10):546-54. doi: 10.1016/j.tem.2014.06.003. Epub 2014 Jul 2.

Zebrafish as a model to explore cell metabolism.

Author information

1
Laboratory of Endothelial Molecular Biology, Vesalius Research Center, Department of Oncology, University of Leuven, Leuven, B-3000, Belgium; Laboratory of Endothelial Molecular Biology, Vesalius Research Center, VIB, Leuven, B-3000, Belgium. Electronic address: massimo.santoro@vib-kuleuven.be.

Abstract

Cell metabolism plays a key role in many essential biological processes. The recent availability of novel technologies and organisms to model cell metabolism in vivo is expanding current knowledge of cell metabolism. In this context, the zebrafish (Danio rerio) is emerging as a valuable model system to learn about the metabolic routes critical for cellular homeostasis. Here, the most recent methods and studies on cell metabolism are summarized, which support the overall value for the zebrafish model system not only to study metabolism but also metabolic disease states. It is envisioned that this small vertebrate system will help in the understanding of pathogenesis for numerous metabolic-related disorders in humans and in the identification of their therapeutic treatments.

KEYWORDS:

drug screening; genetics; metabolic disorders; metabolomics; tools; zebrafish

PMID:
24997878
DOI:
10.1016/j.tem.2014.06.003
[Indexed for MEDLINE]

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