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Nat Neurosci. 2014 Aug;17(8):1043-5. doi: 10.1038/nn.3758. Epub 2014 Jul 6.

A spinal analog of memory reconsolidation enables reversal of hyperalgesia.

Author information

1
Unité de neurosciences cellulaires et moléculaire, Institut universitaire en santé mentale de Québec, Québec, Canada.
2
1] Unité de neurosciences cellulaires et moléculaire, Institut universitaire en santé mentale de Québec, Québec, Canada. [2] Department of Psychiatry and Neuroscience, Université Laval, Québec, Canada.

Abstract

Hyperalgesia arising from sensitization of pain relays in the spinal dorsal horn shares many mechanistic and phenotypic parallels with memory formation. We discovered that mechanical hyperalgesia could be rendered labile and reversible in mice after reactivation of spinal pain pathways in a process analogous to memory reconsolidation. These findings reveal a previously unknown regulatory mechanism underlying hyperalgesia and demonstrate the existence of reconsolidation-like processes in a sensory system.

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PMID:
24997764
PMCID:
PMC4978538
DOI:
10.1038/nn.3758
[Indexed for MEDLINE]
Free PMC Article

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