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Curr Opin Microbiol. 2014 Jun;19:45-51. doi: 10.1016/j.mib.2014.05.023. Epub 2014 Jul 3.

Advanced mass spectrometry technologies for the study of microbial pathogenesis.

Author information

1
Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, United States.
2
Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, United States. Electronic address: R.Caprioli@Vanderbilt.edu.
3
Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address: Eric.Skaar@Vanderbilt.edu.

Abstract

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) has been successfully applied to the field of microbial pathogenesis with promising results, principally in diagnostic microbiology to rapidly identify bacteria based on the molecular profiles of small cell populations. Direct profiling of molecules from serum and tissue samples by MALDI MS provides a means to study the pathogen-host interaction and to discover potential markers of infection. Systematic molecular profiling across tissue sections represents a new imaging modality, enabling regiospecific molecular measurements to be made in situ, in both two-dimensional and three-dimensional analyses. Herein, we briefly summarize work that employs MALDI MS to study the pathogenesis of microbial infection.

PMID:
24997399
PMCID:
PMC4125470
DOI:
10.1016/j.mib.2014.05.023
[Indexed for MEDLINE]
Free PMC Article
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