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Curr Opin Struct Biol. 2014 Jun;26:113-20. doi: 10.1016/j.sbi.2014.06.001. Epub 2014 Jul 2.

Different subunits belonging to the same protein complex often exhibit discordant expression levels and evolutionary properties.

Author information

1
Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
2
Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: emmanuel.levy@weizmann.ac.il.

Abstract

Hetero-oligomeric protein complexes are involved in many of the key processes in cells. Given that the subunits of a complex function together, it has often been expected to find that (i) they are expressed at similar levels in cells; (ii) they are simultaneously present or absent in genomes; and that (iii) the effects on fitness of deleting their genes should be similar. Such a coherence is, however, often found to be weak or absent. Multi-functionality of subunits and mechanisms of complex assembly are discussed as possible sources for the lack of coherence.

PMID:
24997301
DOI:
10.1016/j.sbi.2014.06.001
[Indexed for MEDLINE]
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