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Food Chem. 2014 Dec 1;164:363-70. doi: 10.1016/j.foodchem.2014.05.060. Epub 2014 May 20.

Polyphenols of selected peach and plum genotypes reduce cell viability and inhibit proliferation of breast cancer cells while not affecting normal cells.

Author information

1
Embrapa Clima Temperado, BR 392, km 78, 96001-970 Pelotas, RS, Brazil(1); Dpt of Horticultural Sciences and Vegetable & Fruit Improvement Center, Texas A&M University, College Station, TX 77843, United States.
2
Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, United States.
3
Dpt of Horticultural Sciences and Vegetable & Fruit Improvement Center, Texas A&M University, College Station, TX 77843, United States.
4
Dpt of Horticultural Sciences and Vegetable & Fruit Improvement Center, Texas A&M University, College Station, TX 77843, United States. Electronic address: lcisnero@tamu.edu.

Abstract

Polyphenolic extracts and fractions of selected peach and plum genotypes were evaluated for cell viability and antiproliferation activity in vitro against an estrogen independent MDA-MB-435 and estrogen dependent MCF-7 breast cancer cell lines and one non-cancerous breast line MCF-10A. All extracts showed a phenolic dose-dependent cytotoxic effect against MDA-MB-435, weak activity against MCF-7 and small or no activity against MCF-10A. Genotype phenolic profiles showed varying degrees of polyphenolic mixtures. Fractionation of peach BY00P6653 extracts gave 4 fractions, with fraction F-I (caffeic acid derivatives) showing a strong activity against MDA-MB-435 followed by fraction F-II (anthocyanins). Induced-apoptosis by F-I on MDA-MB-435 was confirmed by Tunnel nuclear staining of cells with apoptotic DNA fragmentation (0-100 μg/mL) with no effects in normal cells (0-200 μg/mL). Selected stone fruit genotypes can be added to the list of fruits with cytotoxic effects against breast cancer cells while not affecting normal cells.

KEYWORDS:

Apoptosis; Breast cancer; Polyphenols; Prunus persica; Prunus salicina; Selective cytotoxicity

PMID:
24996346
DOI:
10.1016/j.foodchem.2014.05.060
[Indexed for MEDLINE]

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