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Cell. 2014 Jul 3;158(1):11-2. doi: 10.1016/j.cell.2014.06.021.

YAP1 takes over when oncogenic K-Ras slumbers.

Author information

1
Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt, Germany. Electronic address: greten@gsh.uni-frankfurt.de.

Abstract

It is of great therapeutic importance to understand why tumors relapse after the failure of therapies targeting oncogenes to which cancer cells are addicted. In this issue, Kapoor et al. and Shao et al. identify the transcriptional coactivator YAP1 as a central driver of compensation for the loss of K-Ras signaling in K-Ras-dependent cancers.

PMID:
24995973
DOI:
10.1016/j.cell.2014.06.021
[Indexed for MEDLINE]
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