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Gut Pathog. 2014 Jun 25;6:26. doi: 10.1186/1757-4749-6-26. eCollection 2014.

Co-occurrence of driver and passenger bacteria in human colorectal cancer.

Author information

1
Department of Infectious Diseases, The First People's Hospital of Yunnan Province, Kunming 650032, China.
2
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
3
Department of Gastroenterology, The First People's Hospital of Yunnan Province, Kunming 650032, China.
4
Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China.
5
State Key Laboratory of Genetic Resources and Evolution, Laboratory of Evolutionary & Functional Genomics, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
#
Contributed equally

Abstract

BACKGROUND:

Both genetic and epigenetic alterations have been reported to act as driving forces of tumorigenesis in colorectal cancer (CRC), but a growing body of evidence suggests that intestinal microbiota may be an aetiological factor in the initiation and progression of CRC. Recently, the "driver-passenger" model for CRC has connected these different factors, but little has been done to characterize the CRC gut microbiome.

FINDINGS:

Building on the driver-passenger model, we used 454 pyrosequencing of bacterial 16S rRNA genes associated with 10 normal, 10 adenoma, and 8 tumor biopsy samples, and found 7 potential driver bacterial genera and 12 potential passenger bacterial genera (7 being pro-inflammatory and 5 anti-inflammatory). Further analysis also showed certain co-expression patterns among different clusters of bacteria that may potentially be related to the promotion or progression of gut cancers.

CONCLUSIONS:

The present findings provide preliminary experimental evidence supporting the proposition of bacterial "driver-passenger model" for CRC, and identified potentially novel microbial agents that may be connected to risk of CRC in a Han Chinese population.

KEYWORDS:

CRC; Co-occurrence; Driver bacteria; Passenger bacteria

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