Format

Send to

Choose Destination
Mediators Inflamm. 2014;2014:396204. doi: 10.1155/2014/396204. Epub 2014 Jun 8.

Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease.

Author information

1
Institut Clínic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Sabino de Arana 1, 08028 Barcelona, Spain.
2
Institut Clínic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Sabino de Arana 1, 08028 Barcelona, Spain ; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
3
Rheumatology Department, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain.
4
Autoimmune Disease Department, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain.

Abstract

The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behçet's disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-12p70, IL-17A, tumor necrosis factor-α (TNF-α), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-γ and TNF-α were significantly increased in patients with active uveitis associated to BD compared to controls (P < 0.05). IFN-γ, TNF-α, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P < 0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P < 0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-γ, TNF-α, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.

PMID:
24994946
PMCID:
PMC4068062
DOI:
10.1155/2014/396204
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Limited Icon for PubMed Central
Loading ...
Support Center