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J Cell Sci. 2014 Aug 1;127(Pt 15):3217-25. doi: 10.1242/jcs.146142. Epub 2014 Jul 2.

Integrins and epithelial cell polarity.

Author information

1
Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
2
Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK cstreuli@manchester.ac.uk.

Abstract

Cell polarity is characterised by differences in structure, composition and function between at least two poles of a cell. In epithelial cells, these spatial differences allow for the formation of defined apical and basal membranes. It has been increasingly recognised that cell-matrix interactions and integrins play an essential role in creating epithelial cell polarity, although key gaps in our knowledge remain. This Commentary will discuss the mounting evidence for the role of integrins in polarising epithelial cells. We build a model in which both inside-out signals to polarise basement membrane assembly at the basal surface, and outside-in signals to control microtubule apical-basal orientation and vesicular trafficking are required for establishing and maintaining the orientation of epithelial cell polarity. Finally, we discuss the relevance of the basal integrin polarity axis to cancer. This article is part of a Minifocus on Establishing polarity.

KEYWORDS:

+TIPS; Basement membrane; Breast; Endocytosis; Epithelium; ILK; Integrin; Laminin; Mammary; Microtubule; Polarity

Comment in

PMID:
24994933
PMCID:
PMC4117227
DOI:
10.1242/jcs.146142
[Indexed for MEDLINE]
Free PMC Article

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