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Eur J Immunol. 1989 Apr;19(4):771-3.

Ontogeny of expression of UCHL1 antigen on TcR-1+ (CD4/8) and TcR delta+ T cells.

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Department of Pediatrics, University of Colorado School of Medicine, Denver 80262.


The frequency of blood mononuclear cells expressing the 180-kDa splice variant of the common leukocyte antigen identified by the UCHL1 monoclonal antibody (a characteristic of post-thymic cells which have been through a cycle of stimulation) rose in a logarithmic relationship to age between birth and 16 years. At birth only a low frequency of CD4+ (negative for CD 25) and no CD8+ T cells expressed UCHL1. The subsequent increase in UCHL1 expression occurred in parallel on T cells expressing alpha/beta receptors and gamma/delta receptors, suggesting that these subsets participated in post-thymic proliferation in proportion to their numbers in blood. The frequency of UCHL1 expression on CD8 cells was 5-15% less than on CD4 cells.

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