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Cold Spring Harb Perspect Med. 2014 Jul 3;4(10). pii: a013631. doi: 10.1101/cshperspect.a013631.

Markers of epidermal stem cell subpopulations in adult mammalian skin.

Author information

1
Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, United Kingdom Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom.
2
Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom.

Abstract

The epidermis is the outermost layer of mammalian skin and comprises a multilayered epithelium, the interfollicular epidermis, with associated hair follicles, sebaceous glands, and eccrine sweat glands. As in other epithelia, adult stem cells within the epidermis maintain tissue homeostasis and contribute to repair of tissue damage. The bulge of hair follicles, where DNA-label-retaining cells reside, was traditionally regarded as the sole epidermal stem cell compartment. However, in recent years multiple stem cell populations have been identified. In this review, we discuss the different stem cell compartments of adult murine and human epidermis, the markers that they express, and the assays that are used to characterize epidermal stem cell properties.

PMID:
24993676
PMCID:
PMC4200210
DOI:
10.1101/cshperspect.a013631
[Indexed for MEDLINE]
Free PMC Article

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