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Adv Drug Deliv Rev. 2014 Aug;75:141-8. doi: 10.1016/j.addr.2014.06.008. Epub 2014 Jun 30.

Emerging aerosol drug delivery strategies: from bench to clinic.

Author information

1
Virginia Commonwealth University School of Medicine, Children's Hospital of Richmond at VCU, 1001 East Marshall St., PO Box 980646, Richmond, VA 23298, USA; Division of Pediatric Pulmonary, Department of Pediatrics, Virginia Commonwealth University School of Medicine, Children's Hospital of Richmond at VCU, PO Box 980315, Richmond, VA 23298, USA. Electronic address: brubin@vcu.edu.
2
Virginia Commonwealth University School of Medicine, Children's Hospital of Richmond at VCU, 1001 East Marshall St., PO Box 980646, Richmond, VA 23298, USA; Division of Pediatric Pulmonary, Department of Pediatrics, Virginia Commonwealth University School of Medicine, Children's Hospital of Richmond at VCU, PO Box 980315, Richmond, VA 23298, USA. Electronic address: rwwilliams@vcu.edu.

Abstract

Patients with tracheostomies, those requiring mechanical ventilation, and those too small or compromised for conventional devices, are realizing the benefits of increasingly sophisticated aerosol delivery systems. New medicines and novel aerosol formulations, have enhanced our ability to treat lung disease, and are opening the doors for therapy to treat diseases like diabetes, pulmonary hypertension, and cancer. Progress in the aerosol delivery of drugs has been spurred by the significant benefits, including ease of use, patient comfort, greater selectivity of effect, and the potential to decrease side effects.

KEYWORDS:

Aerosol therapy; Engineered particle; Nebulizer; Pressurized metered dose inhaler; Vibrating mesh nebulizer

PMID:
24993613
DOI:
10.1016/j.addr.2014.06.008
[Indexed for MEDLINE]

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