Format

Send to

Choose Destination
Neurochem Res. 2015 Feb;40(2):301-7. doi: 10.1007/s11064-014-1373-4. Epub 2014 Jul 4.

Advances in astrocyte-targeted approaches for stroke therapy: an emerging role for mitochondria and microRNAS.

Author information

1
Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA.

Abstract

Astrocytes are critical regulators of neuronal function and an effective target for stroke therapy in animal models. Identifying individual targets with the potential for simultaneous activation of multiple downstream pathways that regulate astrocyte homeostasis may be a necessary element for successful clinical translation. Mitochondria and microRNAs each represent individual targets with multi-modal therapeutic potential. Mitochondria regulate metabolism and apoptosis, while microRNAs have the capacity to bind and inhibit numerous mRNAs. By combining strategies targeted at maintaining astrocyte function during and following cerebral ischemia, a synergistic therapeutic effect may be achieved.

PMID:
24993363
PMCID:
PMC4284142
DOI:
10.1007/s11064-014-1373-4
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center