Format

Send to

Choose Destination
See comment in PubMed Commons below
Pediatr Neurol. 2014 Sep;51(3):324-9. doi: 10.1016/j.pediatrneurol.2014.05.033. Epub 2014 Jun 6.

Effects of topiramate on language functions in newly diagnosed pediatric epileptic patients.

Author information

1
Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Jeonbuk, Korea. Electronic address: sunjun@jbnu.ac.kr.
2
Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Jeonbuk, Korea.

Abstract

BACKGROUND:

The aim of this study was to characterize the effects of topiramate on language functions in newly diagnosed pediatric epileptic patients.

METHODS:

Thirty-eight newly diagnosed epileptic patients were assessed using standard language tests. Data were collected before and after beginning topiramate during which time a monotherapy treatment regimen was maintained. Language tests included the Test of Language Problem Solving Abilities, a Korean version of the Peabody Picture Vocabulary Test. We used language tests in the Korean version because all the patients were spoken Korean exclusively in their families.

RESULTS:

All the language parameters of Test of Language Problem Solving Abilities worsened after initiation of topiramate (determine cause, 13.2 ± 4.8 to 11.2 ± 4.3; problem solving, 14.8 ± 6.0 to 12.8 ± 5.0; predicting, 9.8 ± 3.6 to 8.8 ± 4.6). Patients given topiramate exhibited a shortened mean length of utterance in words during response (determine cause, 4.8 ± 0.9 to 4.3 ± 0.7; making inference, 4.5 ± 0.8 to 4.1 ± 1.1; predicting, 5.2 ± 1.0 to 4.7 ± 0.6; P < 0.05), provided ambiguous answers during the testing, exhibited difficulty in selecting appropriate words, took more time to provide answers, and used incorrect grammar. However, there were no statistically significant changes in the receptive language of patients after taking topiramate (95.4 ± 20.4 to 100.8 ± 19.1).

CONCLUSIONS:

Our data suggest that topiramate may have negative effects on problem-solving abilities in children. We recommend performing language tests should be considered in children being treated with topiramate.

KEYWORDS:

children; epilepsy; language function; topiramate

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center