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Head Neck. 2015 Dec;37(12):1799-807. doi: 10.1002/hed.23839. Epub 2015 Jun 20.

Enteral glutamine supplementation in surgical patients with head and neck malignancy: A randomized controlled trial.

Author information

1
Department of Otorhinolaryngology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
2
School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan, Malaysia.
3
Department of Oral and Maxillofacial Surgery, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Abstract

BACKGROUND:

Glutamine supplementation is a novel approach to perioperative nutritional management.

METHODS:

This study was a prospective randomized clinical trial of effects of enteral glutamine supplementation in surgical patients with head and neck malignancy in a tertiary center. This study measured the effects of supplementation within 4 weeks of the postoncologic surgical period in relation to fat-free mass, serum albumin, and quality of life scores.

RESULTS:

The study population consisted of 44 patients. There was significant difference in serum albumin (p < .001), fat-free mass (p < .001), and quality of life scores (p < .05) between control and interventional groups. Significant correlation exists between fat-free mass and quality of life score difference in our study population (p < .05).

CONCLUSION:

Enteral glutamine supplementation significantly improves fat-free mass, serum albumin, and quality of life scores postoperatively and maintenance of lean body mass correlated with improved postoperative outcomes in terms of the patient's quality of life.

KEYWORDS:

glutamine; head and neck; malignancy

PMID:
24992652
DOI:
10.1002/hed.23839
[Indexed for MEDLINE]

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