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Neuron. 2014 Jul 2;83(1):27-49. doi: 10.1016/j.neuron.2014.06.007.

Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases.

Author information

1
Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA; Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA. Electronic address: lmei@gru.edu.
2
Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany. Electronic address: nave@em.mpg.de.

Abstract

Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility genes for diseases such as schizophrenia (SZ) and bipolar disorder. Recent studies have revealed complex Nrg/Erbb signaling networks that regulate the assembly of neural circuitry, myelination, neurotransmission, and synaptic plasticity. Evidence indicates there is an optimal level of NRG/ERBB signaling in the brain and deviation from it impairs brain functions. NRGs/ERBBs and downstream signaling pathways may provide therapeutic targets for specific neuropsychiatric symptoms.

PMID:
24991953
PMCID:
PMC4189115
DOI:
10.1016/j.neuron.2014.06.007
[Indexed for MEDLINE]
Free PMC Article

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