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Biomed Res Int. 2014;2014:527895. doi: 10.1155/2014/527895. Epub 2014 Jun 4.

MicroRNAs in autoimmune diseases.

Qu Z1, Li W1, Fu B1.

Author information

1
State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of the Ministry of Agriculture, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China.

Abstract

Autoimmune diseases (ADs) are featured by body's immune responses being directed towards its own specific target organs or multiple organ systems, causing persistent inflammation and consequent tissue damage. miRNAs are small noncoding RNAs in a size of approximately 22‚ÄČnt that play important regulatory roles in many organisms by cleavage or translational inhibition of targeted mRNAs. Many miRNAs are reported to be differentially expressed in ADs and may play a pivotal role in regulating immune responses and autoimmunity. In this review, current research progress in the miRNAs in ADs was elucidated.

PMID:
24991561
PMCID:
PMC4065654
DOI:
10.1155/2014/527895
[Indexed for MEDLINE]
Free PMC Article
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