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Allergy Asthma Immunol Res. 2014 Jul;6(4):316-24. doi: 10.4168/aair.2014.6.4.316. Epub 2014 Jun 10.

Systemic Inflammation in Older Adults With Asthma-COPD Overlap Syndrome.

Author information

1
Respiratory Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China. ; Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle; Hunter Medical Research Institute, Newcastle, NSW, Australia. ; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton, NSW, Australia.
2
Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle; Hunter Medical Research Institute, Newcastle, NSW, Australia. ; School of Nursing and Midwifery, Faculty of Health, University of Newcastle, NSW, Australia. ; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton, NSW, Australia.
3
Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle; Hunter Medical Research Institute, Newcastle, NSW, Australia. ; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton, NSW, Australia. ; Woolcock Institute of Medical Research, Sydney NSW, Australia.
4
Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle; Hunter Medical Research Institute, Newcastle, NSW, Australia. ; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton, NSW, Australia.

Abstract

PURPOSE:

The role of systemic inflammation on asthma-COPD overlap syndrome is unknown. This study aimed to examine systemic inflammation in asthma-COPD overlap syndrome, and to identify associations between clinical characteristics and inflammatory mediators in asthma-COPD overlap syndrome.

METHODS:

In 108 adults older than 55 years comprising healthy controls (n=29), asthma (n=16), COPD (n=21) and asthma-COPD overlap syndrome (n=42), serum high sensitivity C-reactive protein and Interleukin 6 (IL-6) were assayed. Spirometry, induced sputum, quality of life, comorbidities and medications were assessed, and their associations with asthma-COPD overlap syndrome were analyzed using logistic regression. Associations between systemic inflammatory mediators and clinical characteristics were tested in multivariate linear regression models.

RESULTS:

Patients with asthma-COPD overlap syndrome had significantly elevated IL-6 levels compared with healthy controls and asthmatics. Age, comorbidity index and IL-6 level were independently associated with asthma-COPD overlap syndrome. FEV1% predicted was inversely associated with IL-6 level, and cardiovascular disease was associated with an increased IL-6 level. Systemic markers were not associated with airway inflammation.

CONCLUSIONS:

Systemic inflammation is commonly present in asthma-COPD overlap syndrome, and asthma-COPD overlap syndrome resembled COPD in terms of systemic inflammation. IL-6 is a pivotal inflammatory mediator that may be involved in airflow obstruction and cardiovascular disease and may be an independent treatment target.

KEYWORDS:

Ageing; C-reactive protein; asthma; comorbidity; interleukin-6; obstructive airway disease

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