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Clin Infect Dis. 2014 Oct;59(7):976-81. doi: 10.1093/cid/ciu509. Epub 2014 Jul 2.

Trends in HCV RNA testing among HCV antibody-positive persons in care, 2003-2010.

Author information

1
Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia.
2
Henry Ford Health System, Detroit, Michigan.
3
Kaiser Permanente, Honolulu, Hawaii.
4
Geisinger Health System, Danville, Pennsylvania.
5
Kaiser Permanente Northwest, Portland, Oregon.

Abstract

BACKGROUND:

A test for hepatitis C virus (HCV) RNA is essential to identify persons with active, or current, HCV infection. We assessed trends in HCV RNA testing following a positive HCV antibody result among persons in 4 large healthcare organizations.

METHODS:

Data collected from adults with ≥2 clinical encounters during 2003-2010 were analyzed to determine the frequency of, interval between, and factors associated with having an RNA test after a first positive HCV antibody test.

RESULTS:

From 2003-2010, 5860 persons had a positive antibody test, of whom 3570 (60.9%) had a follow-up RNA test. During this period, the annual frequency of persons with an eventual RNA test did not change significantly; however, the fraction of persons who had the follow-up RNA test within 6 months improved significantly, from 45% in 2003 to 57% in 2010 (P < .001, for trend). Persons born during 1945-1965, men, and those with annual income <$30 000 (by census geocode) were less likely to have had a follow-up RNA test done within 6 months of a positive antibody test.

CONCLUSIONS:

Less than two-thirds of persons with a positive HCV antibody test had a follow-up RNA test. Rapid ascertainment of HCV infection status with reflex testing to RNA is critical to identify persons eligible for treatment.

KEYWORDS:

diagnosis; hepatitis C virus; infection; testing

PMID:
24991025
DOI:
10.1093/cid/ciu509
[Indexed for MEDLINE]
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