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Adv Healthc Mater. 2015 Jan 7;4(1):58-64. doi: 10.1002/adhm.201400252. Epub 2014 Jul 2.

Collagen scaffold arrays for combinatorial screening of biophysical and biochemical regulators of cell behavior.

Author information

1
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 104 RAL, 600 S. Mathews Ave., Urbana, IL, 61801, USA.

Abstract

Arrays of 3D macroporous collagen scaffolds with orthogonal gradations of structural and biomolecular cues are described. Gradient maker technology is applied to create linear biomolecular gradients within microstructurally distinct sections of a single CG scaffold array. The array set up is used to explore cell behaviors including proliferation and regulation of stem cell fate.

KEYWORDS:

arrays; collagen; freeze-drying; gradients; mesenchymal stem cells

PMID:
24989480
PMCID:
PMC4282613
DOI:
10.1002/adhm.201400252
[Indexed for MEDLINE]
Free PMC Article

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