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PLoS One. 2014 Jul 2;9(7):e100903. doi: 10.1371/journal.pone.0100903. eCollection 2014.

The effects of mind-body therapies on the immune system: meta-analysis.

Author information

  • 1Center for Integrative Medicine, Division of Rheumatology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, United States of America.
  • 2Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience, University of California Los Angeles, Los Angeles, California, United States of America.
  • 3Nutrition/Infection Unit, Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts, United States of America.

Abstract

IMPORTANCE:

Psychological and health-restorative benefits of mind-body therapies have been investigated, but their impact on the immune system remain less defined.

OBJECTIVE:

To conduct the first comprehensive review of available controlled trial evidence to evaluate the effects of mind-body therapies on the immune system, focusing on markers of inflammation and anti-viral related immune responses.

METHODS:

Data sources included MEDLINE, CINAHL, SPORTDiscus, and PsycINFO through September 1, 2013. Randomized controlled trials published in English evaluating at least four weeks of Tai Chi, Qi Gong, meditation, or Yoga that reported immune outcome measures were selected. Studies were synthesized separately by inflammatory (n = 18), anti-viral related immunity (n = 7), and enumerative (n = 14) outcomes measures. We performed random-effects meta-analyses using standardized mean difference when appropriate.

RESULTS:

Thirty-four studies published in 39 articles (total 2, 219 participants) met inclusion criteria. For inflammatory measures, after 7 to 16 weeks of mind-body intervention, there was a moderate effect on reduction of C-reactive protein (effect size [ES], 0.58; 95% confidence interval [CI], 0.04 to 1.12), a small but not statistically significant reduction of interleukin-6 (ES, 0.35; 95% CI, -0.04 to 0.75), and negligible effect on tumor necrosis factor-α (ES, 0.21; 95% CI, -0.15 to 0.58). For anti-viral related immune and enumerative measures, there were negligible effects on CD4 counts (ES, 0.15; 95% CI, -0.04 to 0.34) and natural killer cell counts (ES, 0.12, 95% CI -0.21 to 0.45). Some evidence indicated mind-body therapies increase immune responses to vaccination.

CONCLUSIONS:

Mind-body therapies reduce markers of inflammation and influence virus-specific immune responses to vaccination despite minimal evidence suggesting effects on resting anti-viral or enumerative measures. These immunomodulatory effects, albeit incomplete, warrant further methodologically rigorous studies to determine the clinical implications of these findings for inflammatory and infectious disease outcomes.

PMID:
24988414
PMCID:
PMC4079606
DOI:
10.1371/journal.pone.0100903
[PubMed - indexed for MEDLINE]
Free PMC Article
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