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Curr Osteoporos Rep. 2014 Sep;12(3):300-12. doi: 10.1007/s11914-014-0222-3.

Bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment.

Author information

1
Department of Pediatrics, The Children's Hospital of Philadelphia, The University of Pennsylvania Perelman School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA, 19104, USA, moab@email.chop.edu.

Abstract

Skeletal abnormalities are commonly seen in children and adolescents with leukemia. The spectrum ranges from mild pain to debilitating osteonecrosis (ON) and fractures. In this review, we summarize the skeletal manifestations, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life observed in children and adolescents with leukemia.

PMID:
24986711
PMCID:
PMC4131149
DOI:
10.1007/s11914-014-0222-3
[Indexed for MEDLINE]
Free PMC Article

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