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Head Neck. 2015 Dec;37(12):1750-5. doi: 10.1002/hed.23821. Epub 2015 Jun 22.

Incidence of hospitalization in patients with head and neck cancer treated with intensity-modulated radiation therapy.

Author information

1
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
2
Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
3
Department of Medicine, Division of Medical Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
4
Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania.

Abstract

BACKGROUND:

Patients with primary head and neck cancer managed with radiation therapy (RT) +/- chemotherapy may experience significant treatment-related toxicities. We assessed hospitalization as a metric for severe treatment-related toxicities and evaluated patient and treatment factors for possible association.

METHODS:

A retrospective review was performed on 147 patients with head and neck cancer treated with definitive or adjuvant intensity-modulated radiation therapy (IMRT) +/- chemotherapy. Multiple Poisson regression model was used to analyze relationships between patient or treatment factors and number of hospital stays during RT and within 8 weeks after RT.

RESULTS:

Multivariate analysis showed preexisting diabetes or pulmonary disease, primary carcinoma of oral cavity, and prescribed radiation dose (p < .05) were associated with increased number of patient hospital stays during or shortly after RT.

CONCLUSION:

We found that 34.7% of patients experienced a chemoradiation toxicity-related hospitalization during or shortly after treatment. Prior pulmonary disease, diabetes, and increasing prescribed radiation dose were associated with increased hospital stays.

KEYWORDS:

chemoradiation; head and neck cancer; hospitalization; intensity-modulated radiation therapy (IMRT); percutaneous endoscopic gastrostomy (PEG) tube; toxicity

PMID:
24986324
DOI:
10.1002/hed.23821
[Indexed for MEDLINE]
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