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Trends Mol Med. 2014 Aug;20(8):437-48. doi: 10.1016/j.molmed.2014.05.006. Epub 2014 Jun 28.

Noncoding RNAs: key molecules in understanding and treating pain.

Author information

1
Institute for Pharmacology, Im Neuenheimer Feld 366, Medical Faculty Heidelberg, Heidelberg University, 69120 Heidelberg, Germany; Molecular Medicine Partnership Unit with European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany. Electronic address: kiran.bali@pharma.uni-heidelberg.de.
2
Institute for Pharmacology, Im Neuenheimer Feld 366, Medical Faculty Heidelberg, Heidelberg University, 69120 Heidelberg, Germany; Molecular Medicine Partnership Unit with European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany. Electronic address: rohini.kuner@pharma.uni-heidelberg.de.

Abstract

Although noncoding RNAs (ncRNAs) were initially considered to be transcriptional byproducts, recent technological advances have led to a steady increase in our understanding of their importance in gene regulation and disease pathogenesis. In keeping with these developments, pain research is also experiencing rapid growth in the investigation of links between ncRNAs and pathological pain. Although the initial focus was on analyzing expression and dysregulation of candidate miRNAs, elucidation of other ncRNAs and ncRNA-mediated functional mechanisms in pain modulation has just commenced. Here we review the major ncRNA literature available to date with respect to pain modulation and discuss tools and opportunities available for testing the impact of other types of ncRNA on pain.

KEYWORDS:

chronic pain; lncRNA; miRNA; ncRNA; pain mechanisms

PMID:
24986063
PMCID:
PMC4123187
DOI:
10.1016/j.molmed.2014.05.006
[Indexed for MEDLINE]
Free PMC Article

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