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Transl Psychiatry. 2014 Jul 1;4:e405. doi: 10.1038/tp.2014.47.

Healthy individuals treated with clomipramine: an fMRI study of brain activity during autobiographical recall of emotions.

Author information

1
Department and Institute of Psychiatry, School of Medicine and Hospital das Clínicas, University of São Paulo, São Paulo, Brazil.
2
1] Department of Cognitive Neuroscience, Federal University of the ABC, Santo André, Brazil [2] Department and Institute of Radiology, School of Medicine, University of São Paulo, São Paulo, Brazil.
3
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
4
Department and Institute of Radiology, School of Medicine, University of São Paulo, São Paulo, Brazil.
5
1] Department and Institute of Psychiatry, School of Medicine and Hospital das Clínicas, University of São Paulo, São Paulo, Brazil [2] Laboratory of Psychopharmacology (LIM 23), School of Medicine, USP, São Paulo, Brazil [3] Department of Pharmacology, Institute of Biomedical Sciences, USP, São Paulo, Brazil.

Abstract

Various functional magnetic resonance imaging studies addressed the effects of antidepressant drugs on brain functioning in healthy subjects; however, none specifically investigated positive mood changes to antidepressant drug. Sixteen subjects with no personal or family history of psychiatric disorders were selected from an ongoing 4-week open trial of small doses of clomipramine. Follow-up interviews documented clear positive treatment effects in six subjects, with reduced irritability and tension in social interactions, improved decision making, higher self-confidence and brighter mood. These subjects were then included in a placebo-controlled confirmatory trial and were scanned immediately after 4 weeks of clomipramine use and again 4 weeks after the last dose of clomipramine. The functional magnetic resonance imaging (fMRI) scans were run during emotion-eliciting stimuli. Repeated-measures analysis of variance of brain activity patterns showed significant interactions between group and treatment status during induced irritability (P<0.005 cluster-based) but not during happiness. Individuals displaying a positive subjective response do clomipramine had higher frontoparietal cortex activity during irritability than during happiness and neutral emotion, and higher temporo-parieto-occipital cortex activity during irritability than during happiness. We conclude that antidepressants not only induce positive mood responses but also act upon autobiographical recall of negative emotions.

PMID:
24984192
PMCID:
PMC4080327
DOI:
10.1038/tp.2014.47
[Indexed for MEDLINE]
Free PMC Article
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