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Biomed Res Int. 2014;2014:367103. doi: 10.1155/2014/367103. Epub 2014 May 25.

Molecular profiling and clinical outcome of high-grade serous ovarian cancer presenting with low- versus high-volume ascites.

Author information

1
Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada M5G 2M9 ; Department of Obstetrics and Gynaecology, Trillium Health Partners, 2200 Eglinton Avenue West, Mississauga, ON, Canada L5M 2N1.
2
Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON, Canada M5G 2M9 ; Department of Laboratory Medicine and Pathology, University Health Network, Toronto, ON, Canada M5T 2M9.
3
Princess Margaret Genomics Centre, University Health Network, Toronto, ON, Canada M5G 1L7.
4
Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON, Canada M5G 2M9 ; Department of Laboratory Medicine and Pathology, Trillium Health Partners, Mississauga, ON, Canada L5M 2N1.
5
Hospital for Sick Children and Department of Immunology, University of Toronto, Toronto, ON, Canada M5G 1X8.
6
Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada M5G 2M9 ; Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, Princess Margaret Cancer Centre, Toronto, ON, Canada M5G 2M9.
7
Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada M5T 3L9.

Abstract

Epithelial ovarian cancer consists of multiple histotypes differing in etiology and clinical course. The most prevalent histotype is high-grade serous ovarian cancer (HGSOC), which often presents at an advanced stage frequently accompanied with high-volume ascites. While some studies suggest that ascites is associated with poor clinical outcome, most reports have not differentiated between histological subtypes or tumor grade. We compared genome-wide gene expression profiles from a discovery cohort of ten patients diagnosed with stages III-IV HGSOC with high-volume ascites and nine patients with low-volume ascites. An upregulation of immune response genes was detected in tumors from patients presenting with low-volume ascites relative to those with high-volume ascites. Immunohistochemical studies performed on tissue microarrays confirmed higher expression of proteins encoded by immune response genes and increased tumorinfiltrating cells in tumors associated with low-volume ascites. Comparison of 149 advanced-stage HGSOC cases with differential ascites volume at time of primary surgery indicated low-volume ascites correlated with better surgical outcome and longer overall survival. These findings suggest that advanced stage HGSOC presenting with low-volume ascites reflects a unique subgroup of HGSOC, which is associated with upregulation of immune related genes, more abundant tumor infiltrating cells and better clinical outcomes.

PMID:
24982872
PMCID:
PMC4055662
DOI:
10.1155/2014/367103
[Indexed for MEDLINE]
Free PMC Article

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