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In Vivo. 2014 Jul-Aug;28(4):667-71.

Prevalence of herpes simplex virus 1 and 2 antibodies in patients with autism spectrum disorders.

Author information

1
Department of Clinical Medicine and Surgery-Section of Infectious Diseases, Federico II University of Naples, Naples, Italy ivan.gentile@unina.it.
2
Department of Clinical Medicine and Surgery-Section of Infectious Diseases, Federico II University of Naples, Naples, Italy.
3
Department of Medical Translational Science, Federico II University of Naples, Naples, Italy.
4
Mental Health and Public Medicine, Second University of Naples, Naples, Italy.

Abstract

BACKGROUND/AIM:

The etiology of autism spectrum disorder (ASD) is unknown, even though it is hypothesized that a viral infection could trigger this disorder. The aim of this study was to evaluate the seropositivity rate and antibody level of Herpes Simplex Virus 1 (HSV1) and Herpes Simplex Virus 2 (HSV2) in children with ASD compared to same-aged healthy controls.

PATIENTS AND METHODS:

We compared seropositivity rate and levels of antibodies to HSV1/2 in 54 children with ASD (19 with autistic disorder and 35 with non-autistic ASD) and in 46 controls.

RESULTS:

Seropositivity rate and levels of anti-HSV1/2 were not dissimilar between cases and controls. Exposure to HSV2 was minimal.

CONCLUSION:

Rate of contact with HSV1 and HSV2 assessed by the mean of detection of specific antibodies was similar between children with ASD and healthy controls.

KEYWORDS:

Autism spectrum disorder; HSV1; HSV2; etiopathogenesis

PMID:
24982239
[Indexed for MEDLINE]
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