Format

Send to

Choose Destination
Dev Cell. 2014 Jul 14;30(1):36-47. doi: 10.1016/j.devcel.2014.05.020. Epub 2014 Jun 26.

Regulation of plant stem cell quiescence by a brassinosteroid signaling module.

Author information

1
Department of Molecular Genetics, Center for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB, Bellaterra (Cerdanyola del Vallès), 08193 Barcelona, Spain.
2
Departament d'Estructura i Constituents de la Matèria, Facultat de Física, Universitat de Barcelona, 08028 Barcelona, Spain.
3
Biomedical Genomic Group, Research Unit on Biomedical Informatics (GRIB), Barcelona Biomedical Research park (PRBB), Dr. Aiguader 88, 08003 Barcelona, Spain.
4
INRA, Laboratoire des Interactions Plantes-Microorganismes (LIPM), UMR441, 31326 Castanet-Tolosan, France; CNRS, Laboratoire des Interactions Plantes-Microorganismes (LIPM), UMR2594, 31326 Castanet-Tolosan, France.
5
Fédération de Recherche 3450, Plateforme Imagerie, Pôle de Biotechnologie Végétale, 31320 Castanet-Tolosan, France.
6
Center for Organismal Studies (COS), University of Heidelberg, 69120 Heidelberg, Germany.
7
Department of Biology, HHMI and Duke Center for Systems Biology, Duke University, Durham, NC 27708, USA.
8
Department of Molecular Genetics, Center for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB, Bellaterra (Cerdanyola del Vallès), 08193 Barcelona, Spain. Electronic address: ana.cano@cragenomica.es.

Erratum in

  • Dev Cell. 2015 Apr 20;33(2):238.

Abstract

The quiescent center (QC) maintains the activity of the surrounding stem cells within the root stem cell niche, yet specific molecular players sustaining the low rate of QC cell division remain poorly understood. Here, we identified a R2R3-MYB transcription factor, BRAVO (BRASSINOSTEROIDS AT VASCULAR AND ORGANIZING CENTER), acting as a cell-specific repressor of QC divisions in the primary root of Arabidopsis. Ectopic BRAVO expression restricts overall root growth and ceases root regeneration upon damage of the stem cells, demonstrating the role of BRAVO in counteracting Brassinosteroid (BR)-mediated cell division in the QC cells. Interestingly, BR-regulated transcription factor BES1 (BRI1-EMS SUPRESSOR 1) directly represses and physically interacts with BRAVO in vivo, creating a switch that modulates QC divisions at the root stem cell niche. Together, our results define a mechanism for BR-mediated regulation of stem cell quiescence in plants.

PMID:
24981610
DOI:
10.1016/j.devcel.2014.05.020
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center