Format

Send to

Choose Destination
Nat Rev Genet. 2014 Aug;15(8):531-40. doi: 10.1038/nrg3728. Epub 2014 Jul 1.

Comparative genetics of longevity and cancer: insights from long-lived rodents.

Author information

1
University of Rochester, Rochester, New York 14627, USA.
2
Albert Einstein College of Medicine, Bronx, New York 10461, USA.
3
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats. Recent progress in rodent comparative biology, together with the emergence of whole-genome sequence information, has opened opportunities for the discovery of genetic factors that control longevity and cancer susceptibility.

PMID:
24981598
PMCID:
PMC4353926
DOI:
10.1038/nrg3728
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center