Format

Send to

Choose Destination
Exp Oncol. 2014 Jun;36(2):90-3.

Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer.

Author information

1
Peoples' Friendship University of Russia, Moscow 117198, Russia.
2
ZAO "MiraxBioPharma", Moscow 121248, Russia.
3
Moscow State Medical Stomatological University (MGMSU), Moscow 127473, Russia.
4
National Research Centre (NRC "Kurchatov Institute"), Moscow 123182, Russia.

Abstract

AIM:

Preclinical study of the specific anticancer pharmacological activity of the formulation containing active substance 3,3ʹ-diindolylmethane (DIM), cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E), in vivo in a xenograft animal model of LNCaP.

MATERIALS AND METHODS:

The DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) formulation was intragastrically administered to BALB/c-nude (nu/nu) mice during 33 days post inoculation at the dose of 133 mg/kg/day. Antitumor activity of the test drug was estimated by the rate of tumor growth inhibition (T/C% - treated versus control), dividing the tumor volumes from treatment groups with the control groups.

RESULTS:

Statistically significant tumor xenograft regressions have been shown in group which received the DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) on the 37(th) day of observation post inoculation. The highest antitumor activity was achieved on the 39(th) day (T/C = 16,8%). Therapeutic effect lasts for 6 days after the end of therapy period.

CONCLUSION:

Our findings demonstrate inhibitory effect of the formulation on tumor development in the xenograft animal model due to the tumor growth rate reduction.

PMID:
24980762
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for MORION LLC
Loading ...
Support Center