Send to

Choose Destination
See comment in PubMed Commons below
Retina. 2014 Oct;34(10):2044-52. doi: 10.1097/IAE.0000000000000200.

Outcomes of treatment of pediatric choroidal neovascularization with intravitreal antiangiogenic agents: the results of the KKESH International Collaborative Retina Study Group.

Author information

*Ophthalmology Service, Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; †Department of Ophthalmology, Professor Albrecht Meerhoff Clinic, American University of Beirut, Beirut, Lebanon; ‡Charles Retina Institute, Memphis, Tennessee; §San Giuseppe Hospital, University Eye Clinic, Milan, Italy; ¶Department of Ophthalmology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico; **University of Valencia School of Medicine, and Department of Ophthalmology, Hospital Universitario La Fe de Valencia, Valencia, Spain; ††L. V. Prasad Eye Institute, Hyderabad, India; ‡‡Servicio de Oftalmologia, Instituto de la Vision, Hospital Universitario Austral, Buenos Aires, Argentina; §§Clinica Professor Albrecht Meerhoff, Montevideo, Uruguay; ¶¶Department of Ophthalmology and Visual Sciences, University of Chicago at Illinois, Chicago, Illinois; and ***Retina Division, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.



To evaluate safety and clinical results of intravitreal antiangiogenic agents for choroidal neovascularization in pediatric patients.


Retrospective, multicenter, interventional case series. A total of 45 eyes of 39 pediatric patients with choroidal neovascularization of various etiologies were treated with intravitreal injection of antiangiogenic agents (1.25 mg per 0.05 mL of bevacizumab or 0.5 mg per 0.05 mL of ranibizumab).


There were 24 girls and 15 boys with group median age of 13 years (range, 3-17 years). Mean follow-up period was 12.8 months (range, 3-60 months). Median visual acuity in terms of logarithm of the minimum angle of resolution at presentation and last follow-up was 0.87 and 0.7, respectively (P = 0.0003). Mean and median number of injections received over the follow-up period was 2.2 and 1, respectively. At the last follow-up, 22 eyes (48%) gained more than 3 lines of vision and 27 eyes (60%) had final visual acuity 20/50 or better. Nine eyes (20%) did not improve and had severe vision loss (20/200 or worse).


Intravitreal antiangiogenic therapy for choroidal neovascularization in pediatric patients seems temporarily safe and effective in majority of affected eyes. Because of the rarity and character of this condition, it is unlikely that any clinical trials will soon take place to study this or other treatment option.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wolters Kluwer
    Loading ...
    Support Center