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Ann Neurol. 2014 Aug;76(2):305-9. doi: 10.1002/ana.24208. Epub 2014 Jul 9.

Cerebrospinal fluid aquaporin-4 antibody levels in neuromyelitis optica attacks.

Author information

1
Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Abstract

To elucidate immunopathogenetic roles of aquaporin-4 antibodies in the cerebrospinal fluid (CSF) of neuromyelitis optica spectrum disorders (NMOSD), we analyzed aquaporin-4 antibody titers, cellular and inflammatory markers in the CSF collected from 11 aquaporin-4 antibody seropositive patients. The CSF aquaporin-4 antibody levels during attacks (but not in sera) closely correlated with pleocytosis, inflammatory cytokines including interleukin-6 that can regulate antibody-producing plasmablasts, and glial fibrillary acidic protein levels in the CSF. The amount of aquaporin-4 antibodies present in the central nervous system may have therapeutic implications, as it is associated with astrocyte injury and inflammatory responses during NMOSD attacks.

PMID:
24977390
PMCID:
PMC4173125
DOI:
10.1002/ana.24208
[Indexed for MEDLINE]
Free PMC Article

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