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J Thorac Dis. 2014 Jun;6(6):850-5. doi: 10.3978/j.issn.2072-1439.2014.06.03.

Meis1 regulates proliferation of non-small-cell lung cancer cells.

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1
1 Department of Thoracic surgery, 2 Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Abstract

As one of the most common cancers, lung cancer remains to be a major public health problem. Non-small-cell lung adenocarcinoma cancer exhibits higher resistance to chemotherapy than small cell lung cancer, which requires novel strategies. To further understand underlying mechanisms for non-small-cell lung adenocarcinoma cancer cell proliferation, we explored the role of Meis1 in non-small-cell lung adenocarcinoma cancer cells. The results show that Meis1 inhibits non-small-cell lung cancer (NSCLC) cell proliferation. Specific knockdown of Meis1 resulted in strengthened proliferative ability of non-small-cell lung adenocarcinoma cancer cells. Cell cycle analysis indicated that DNA synthesis was increased when Meis1 was down-regulated specifically. As well as histone H3 phosphorylation, which is indicative of mitosis. More importantly, forced Meis1 expression repressed the proliferation of non-small-cell lung adenocarcinoma cancer cell. These data demonstrated Meis1 limits the proliferation of non-small-cell lung adenocarcinoma cancer cell and could potentially represent a therapeutic strategy that may control non-small-cell lung adenocarcinoma cancer cell proliferation.

KEYWORDS:

Meis1; cell cycle; non-small-cell lung cancer (NSCLC); proliferation

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