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Fitoterapia. 2014 Sep;97:224-33. doi: 10.1016/j.fitote.2014.06.014. Epub 2014 Jun 27.

The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms.

Author information

1
Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul 110-799, Korea. Electronic address: jnchun@gmail.com.
2
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, Seoul, 152-742, Korea.
3
Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul 110-799, Korea.
4
Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul 110-799, Korea. Electronic address: jhjeon2@snu.ac.kr.

Abstract

Schisandra chinensis fruit extract (SCE) has traditionally been used as an oriental medicine for the treatment of various human diseases, including cardiovascular disease. Advances in scientific knowledge and analytical technologies provide opportunities for translational research involving S. chinensis; such research may contribute to future drug discovery. To date, emerging experimental evidence supports the therapeutic effects of the SCE or its bioactive lignan ingredients in cardiovascular disease, unraveling the mechanistic basis for their pharmacological actions. In the present review, we highlight SCE and its lignans as promising resources for the development of safe, effective, and multi-targeted agents against cardiovascular disease. Moreover, we offer novel insight into future challenges and perspective on S. chinensis research to future clinical investigations and healthcare strategies.

KEYWORDS:

Cardiovascular disease; Lignans; Molecular mechanism; Schisandra chinensis; Signaling pathway

PMID:
24976588
DOI:
10.1016/j.fitote.2014.06.014
[Indexed for MEDLINE]

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