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J Cardiol. 2015 Mar;65(3):203-7. doi: 10.1016/j.jjcc.2014.05.007. Epub 2014 Jun 26.

Drug-eluting balloons in patients with non-ST elevation acute coronary syndrome.

Author information

1
Department of Cardiovascular Medicine, University Hospital Centre Zagreb, Zagreb, Croatia. Electronic address: kmaricbesic@gmail.com.
2
Department of Cardiovascular Medicine, University Hospital Centre Zagreb, Zagreb, Croatia.
3
Department for Social Medicine and Epidemiology, Medical School, University of Rijeka, Rijeka, Croatia.

Abstract

BACKGROUND:

We compared efficacy of bare-metal stent (BMS) and drug-eluting balloon (DEB) combination vs BMS alone, in patients with non-ST elevation acute coronary syndrome treated with percutaneous coronary intervention (PCI).

METHODS:

Patients with non-ST elevation myocardial infarction (NSTEMI) or unstable angina (UA) were randomized to BMS only or BMS+DEB group. Angiographic follow-up was performed after 6 months. The primary endpoints were binary in-stent restenosis (ISR) and late lumen loss (LLL) and the secondary endpoints were target lesion revascularization (TLR), stent thrombosis (ST), and new acute coronary syndrome (ACS).

RESULTS:

A total of 85 patients were enrolled, 44 (BMS) and 41 (BMS+DEB). The median age was 67 (36-84) years and 68 (80%) were male. Fifty-two patients (61.2%) had NSTEMI and 33 patients (38.8%) UA. There was no difference in patient demographics, risk factors, and clinical characteristics, except for more smokers in the BMS+DEB group 18/41 (43.9%) vs 9/44 (20.5%). At follow-up, no significant difference in binary ISR was found; p=0.593, but LLL was significantly lower in the BMS+DEB group 0.68 (0.00-2.15) mm vs 0.22 (0.00-2.35) mm; p=0.002. The difference in major adverse cardiac events (MACE) rate combining TLR, ST, and ACS, between the groups was also non-significant, 29.5% (BMS) vs 24.4% (BMS+DEB); p=0.835. One patient had a subacute ST (BMS+DEB) due to clopidogrel resistance.

CONCLUSION:

Patients treated with BMS+DEB combination for non-ST elevation acute coronary syndrome had significantly less LLL in comparison to patients treated with BMS alone but without an impact on patient clinical outcomes.

KEYWORDS:

Acute coronary syndrome; Bare-metal stents; Drug-eluting balloons; Late lumen loss

PMID:
24976525
DOI:
10.1016/j.jjcc.2014.05.007
[Indexed for MEDLINE]
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