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Neurologia. 2015 Oct;30(8):465-71. doi: 10.1016/j.nrl.2014.04.014. Epub 2014 Jun 26.

Vagus nerve stimulator implantation for epilepsy in a paediatric hospital: outcomes and effect on quality of life.

[Article in English, Spanish]

Author information

1
Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España. Electronic address: adrianaulate@hotmail.com.
2
Unidad de Epilepsia, Servicio de Neurología y Neurocirugía, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.

Abstract

INTRODUCTION:

Epilepsy, which is present in 0.5% to 1% of the paediatric population, is one of the most frequent childhood neurological disorders. Approximately 20% to 30% of these cases will be drug-resistant. The objective of this study is to describe the impact of vagal nerve stimulation (VNS) on seizures and quality of life in a sample of 30 patients.

METHODS:

Descriptive, retrospective study of all patients with a VNS device implanted between 2008 and 2013 in a single paediatric hospital, based on patients' medical records. Quality of life was assessed using the Spanish scale for quality of life in children with epilepsy, completed by means of a telephone interview.

RESULTS:

We describe a population of 19 boys (64%) and 11 girls (36%) with a mean age at seizure onset of 21 months (1-144 months). The mean age of VNS implantation was 11.89 years. Follow-up periods ranged from 6 to 36 months. Mean reduction in seizures at 6 months was 38%, with a reduction of 43% at 12 months, 42% at 24 months, and 54% at 36 months. At least half of all patients were classified as responders. According to the quality of life scale, 54% of the families rated the effect of VNS as either very good or good while 39% rated it as fair.

CONCLUSIONS:

VNS is a safe palliative treatment that is generally well tolerated. It is partially effective for controlling drug-resistant epilepsy and exerts a positive effect on quality of life.

KEYWORDS:

Drug-resistant epilepsy; Epilepsia refractaria; Epilepsy treatment; Escala de calidad de vida en el niño con epilepsia; Estimulador nervio vago; Quality of life in children with epilepsy scale; Tratamiento de epilepsia refractaria; Vagal nerve stimulator

PMID:
24975345
DOI:
10.1016/j.nrl.2014.04.014
[Indexed for MEDLINE]
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