Macrophages in renal transplantation: Roles and therapeutic implications

Tony Kwan; Huiling Wu; Steven J Chadban

doi:10.1016/j.cellimm.2014.05.009

Macrophages in renal transplantation: Roles and therapeutic implications

Cell Immunol. 2014 Sep-Oct;291(1-2):58-64. doi: 10.1016/j.cellimm.2014.05.009. Epub 2014 Jun 14.

Authors

Tony Kwan¹, Huiling Wu¹, Steven J Chadban²

Affiliations

¹ Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; Collaborative Transplant Research Group, Sydney Medical School, The University of Sydney, Sydney, Australia.
² Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; Collaborative Transplant Research Group, Sydney Medical School, The University of Sydney, Sydney, Australia. Electronic address: steve.chadban@sswahs.nsw.gov.au.

PMID: 24973994
DOI: 10.1016/j.cellimm.2014.05.009

Abstract

The presence of macrophages within transplanted renal allografts has been appreciated for some time, whereby macrophages were viewed primarily as participants in the process of cell-mediated allograft rejection. Recent insights into macrophage biology have greatly expanded our conceptual understanding of the multiple roles of macrophages within the allograft. Distinct macrophage subsets are present within the kidney and these sub-serve discrete functions in promoting and attenuating inflammation, immune modulation and tissue repair. Unraveling the complex roles macrophages play in transplantation will allow identification of potential therapeutic targets to prevent and treat allograft rejection and maximize graft longevity.

Keywords: Innate immunity; Macrophages; Renal transplantation.

Publication types

Review

MeSH terms

Animals
Graft Rejection / immunology*
Humans
Immunomodulation / immunology
Inflammation / immunology*
Kidney / immunology*
Kidney Transplantation / methods*
Mice
Monocytes / immunology*
Reperfusion Injury / immunology*