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Nat Med. 2014 Jul;20(7):790-3. doi: 10.1038/nm.3588. Epub 2014 Jun 29.

Supercooling enables long-term transplantation survival following 4 days of liver preservation.

Author information

1
1] Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Surgery, University Medical Center, Utrecht, the Netherlands.
2
Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
3
1] Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, USA.

Abstract

The realization of long-term human organ preservation will have groundbreaking effects on the current practice of transplantation. Herein we present a new technique based on subzero nonfreezing preservation and extracorporeal machine perfusion that allows transplantation of rat livers preserved for up to four days, thereby tripling the viable preservation duration.

PMID:
24973919
PMCID:
PMC4141719
DOI:
10.1038/nm.3588
[Indexed for MEDLINE]
Free PMC Article

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