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Clin EEG Neurosci. 2015 Oct;46(4):327-30. doi: 10.1177/1550059414529764. Epub 2014 Jun 27.

Creutzfeldt-Jakob-Like Syndrome due to Hypercalcemic Encephalopathy.

Author information

1
Klinik und Poliklinik für Neurologie, Universitätsmedizin Rostock, Rostock, Germany johannes.roesche@med.uni-rostock.de.
2
Klinik für Psychiatrie und Psychotherapie, Universitätsmedizin Rostock, Rostock, Germany.
3
Klinik und Poliklinik für Neurologie, Universitätsmedizin Rostock, Rostock, Germany.

Abstract

Hypercalcemia can cause a subacute syndrome of progressive dementia and marked changes in the electroencephalogram (EEG). We report a case of iatrogenic hypercalcemia with a close correlation between the clinical course and the EEG changes. A 73-year-old woman presented with a subacute syndrome of progressive dementia and bursts of 1.5 to 2 Hz intermittent rhythmic delta activity superimposed on a low-voltage background activity in the EEG. Clinical and EEG abnormalities rapidly resolved after normalization of serum calcium levels. As part of the diagnostic workup of a subacute progressive dementia, a serum calcium level and an EEG should be obtained to detect a Creutzfeldt-Jakob like syndrome in hypercalcemia. Unlike in Creutzfeldt-Jakob disease, and Creutzfeldt-Jakob-like syndrome induced by lithium intoxication, there are rarely myoclonic jerks and periodic discharges in hypercalcemic encephalopathy.

KEYWORDS:

Creutzfeldt-Jakob–like syndrome; delta bursts; hypercalcemia; intermittent rhythmic delta activity; progressive dementia

PMID:
24973231
DOI:
10.1177/1550059414529764
[Indexed for MEDLINE]
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