Format

Send to

Choose Destination
Haematologica. 2014 Oct;99(10):e188-92. doi: 10.3324/haematol.2014.104992. Epub 2014 Jun 27.

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse.

Author information

1
Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany.
2
European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
3
Childhood Leukemia Research Institute and Department of Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, and Tel Aviv University, Israel.
4
Childhood Leukemia Research Institute and Department of Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, and Tel Aviv University, Israel Division of Biological Sciences and Department of Medicine Stem Cell Program, University of California, San Diego, La Jolla, CA, USA.
5
Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany.
6
Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
7
Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
8
Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Germany Department of Pediatric Hematology/Oncology, Medical School Hannover, Germany.
9
Department of Pediatric Hematology/Oncology, Medical School Hannover, Germany.
10
Department of Human Genetics, University of Heidelberg, Germany.
11
Molecular Oncology, Felsenstein Medical Research Center and Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
12
Children's Hospital, University Hospital Tübingen, Germany.
13
Department of Oncology, University Children's Hospital Zurich, Switzerland.
14
European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany Jan.korbel@embl-heidelberg.de Martina.Muckenthaler@med.uni-heidelberg.de Andreas.Kulozik@med.uni-heidelberg.de.
15
Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany Jan.korbel@embl-heidelberg.de Martina.Muckenthaler@med.uni-heidelberg.de Andreas.Kulozik@med.uni-heidelberg.de.

KEYWORDS:

STAT5B; mutation; pediatric T-ALL

PMID:
24972766
PMCID:
PMC4181267
DOI:
10.3324/haematol.2014.104992
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center