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Immunol Lett. 2014 Dec;162(2 Pt A):54-61. doi: 10.1016/j.imlet.2014.05.014. Epub 2014 Jun 24.

Fusobacterium and Enterobacteriaceae: important players for CRC?

Author information

1
Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada.
2
Department of Medicine and Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32611, USA. Electronic address: Christian.Jobin@medicine.ufl.edu.

Abstract

The gut microbiota plays an essential role in regulating intestinal homeostasis through its capacity to modulate various biological activities ranging from barrier, immunity and metabolic function. Not surprisingly, microbial dysbiosis is associated with numerous intestinal disorders including inflammatory bowel diseases (IBD) and colorectal cancer (CRC). In this piece, we will review recent evidence that gut microbial dysbiosis can influence intestinal disease, including colitis and CRC. We will discuss the biological events implicated in the development of microbial dysbiosis and the emergence of CRC-associated microorganisms, focusing on Escherichia coli and Fusobacterium nucleatum. Finally, the mechanisms by which E. coli and F. nucleatum exert potentially carcinogenic effects on the host will be reviewed.

KEYWORDS:

Cancer; Inflammation; Intestine; Microbiome

PMID:
24972311
PMCID:
PMC4259803
DOI:
10.1016/j.imlet.2014.05.014
[Indexed for MEDLINE]
Free PMC Article

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