Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Pharmacol. 2014 Oct 5;740:596-602. doi: 10.1016/j.ejphar.2014.06.024. Epub 2014 Jun 24.

The role of Levosimendan in cardiopulmonary resuscitation.

Author information

1
National and Kapodistrian University of Athens, Medical School, MSc Cardiopulmonary Resuscitation, 75 Mikras Asias Street, 11527 Athens, Greece.
2
National and Kapodistrian University of Athens, Medical School, MSc Cardiopulmonary Resuscitation, 75 Mikras Asias Street, 11527 Athens, Greece; Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece. Electronic address: theodorosxanthos@yahoo.com.

Abstract

Although initial resuscitation from cardiac arrest (CA) has increased over the past years, long term survival rates remain dismal. Epinephrine is the vasopressor of choice in the treatment of CA. However, its efficacy has been questioned, as it has no apparent beneļ¬ts for long-term survival or favorable neurologic outcome. Levosimendan is an inodilator with cardioprotective and neuroprotective effects. Several studies suggest that it is associated with increased rates of return of spontaneous circulation as well as improved post-resuscitation myocardial function and neurological outcome. The purpose of this article is to review the properties of Levosimendan during cardiopulmonary resuscitation (CPR) and also to summarize existing evidence regarding the use of Levosimendan in the treatment of CA.

KEYWORDS:

Cardioprotective; Cardiopulmonary resuscitation; Epinephrine; Levosimendan; Neurological outcome

PMID:
24972240
DOI:
10.1016/j.ejphar.2014.06.024
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center