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Dev Biol. 2014 Sep 1;393(1):109-23. doi: 10.1016/j.ydbio.2014.06.014. Epub 2014 Jun 24.

Symmetry breakage in the vertebrate embryo: when does it happen and how does it work?

Author information

1
University of Hohenheim, Institute of Zoology (220), Garbenstrasse 30, D-70593 Stuttgart, Germany. Electronic address: martin.blum@uni-hohenheim.de.
2
University of Hohenheim, Institute of Zoology (220), Garbenstrasse 30, D-70593 Stuttgart, Germany.
3
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232-0494, USA.
4
Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR 97239-3098, USA.

Abstract

Asymmetric development of the vertebrate embryo has fascinated embryologists for over a century. Much has been learned since the asymmetric Nodal signaling cascade in the left lateral plate mesoderm was detected, and began to be unraveled over the past decade or two. When and how symmetry is initially broken, however, has remained a matter of debate. Two essentially mutually exclusive models prevail. Cilia-driven leftward flow of extracellular fluids occurs in mammalian, fish and amphibian embryos. A great deal of experimental evidence indicates that this flow is indeed required for symmetry breaking. An alternative model has argued, however, that flow simply acts as an amplification step for early asymmetric cues generated by ion flux during the first cleavage divisions. In this review we critically evaluate the experimental basis of both models. Although a number of open questions persist, the available evidence is best compatible with flow-based symmetry breakage as the archetypical mode of symmetry breakage.

KEYWORDS:

Cilia; Ion-flux model; Leftward flow; Left–right asymmetry; Symmetry breakage

PMID:
24972089
PMCID:
PMC4481729
DOI:
10.1016/j.ydbio.2014.06.014
[Indexed for MEDLINE]
Free PMC Article

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