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J Am Coll Nutr. 2014;33(4):288-96. doi: 10.1080/07315724.2013.874913. Epub 2014 Jun 27.

Influence of polyunsaturated fatty acids on blood pressure, resting heart rate and heart rate variability among French Polynesians.

Author information

1
a Axe Santé des Populations et Environnement, Centre de Recherche du CHUQ , Quebec , CANADA (B.V., E.D.); Institut Louis Malardé , Papeete , POLYNÉSIE FRANÇAISE (E.S.); École des Hautes Études en Santé Publique, Département épidémiologie et biostatistiques , Paris , FRANCE (E.C.); IRIS , UMR 8156-997, Bobigny , FRANCE (E.C.); Quebec Heart and Lung Institute, Laval Hospital Research Centre (P.P.), Faculty of Pharmacy (P.P.), Department of Social and Preventive Medicine (E.D.), Laval University , Quebec , CANADA.

Abstract

OBJECTIVE:

To analyze the associations between marine n-3 polyunsaturated fatty acids (PUFAs) and blood pressure (BP), resting heart rate (HR), and heart rate variability (HRV) in a population highly exposed to methylmercury through the diet.

METHODS:

Concentrations of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in erythrocytes membranes were measured in 180 French Polynesian adults (≥18 years) residing in Tubuai, which is a community with a traditional lifestyle, or Papeete, which has a modern lifestyle. HRV was measured using a 2-hour ambulatory electrocardiogram (Holter). Resting HR and BP were measured using standardized protocols and pulse pressure (PP) was calculated as systolic BP - diastolic BP. The associations between n-3 PUFAs and the dependent variables were studied using simple and multiple linear regressions.

RESULTS:

Increasing DHA concentration was associated with lower resting HR (β = -2.57, p = 0.005) and diastolic BP (β = -1.96, p = 0.05) and higher HRV in multivariable models. Specifically, DHA was associated with high frequency (HF; β = 0.19, p = 0.02) and the square root of the mean squared differences of successive R-R intervals (difference between two consecutive R waves; rMSSD; β = 0.08, p = 0.03), which are specific indices of the parasympathetic activity of the autonomic nervous system.

CONCLUSION:

DHA was associated with lower BP and resting HR and higher HRV among French Polynesians who are also exposed to high methylmercury levels.

KEYWORDS:

blood pressure; heart rate variability; methylmercury; n-3 polyunsaturated fatty acids (PUFAs); resting heart rate

PMID:
24971659
DOI:
10.1080/07315724.2013.874913
[Indexed for MEDLINE]

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