Format

Send to

Choose Destination
Gene. 2014 Sep 1;547(2):175-85. doi: 10.1016/j.gene.2014.06.050. Epub 2014 Jun 24.

Primary cilium: an elaborate structure that blocks cell division?

Author information

1
The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
2
The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wxyang@spermlab.org.

Abstract

A primary cilium is a microtubule-based membranous protrusion found in almost all cell types. A primary cilium has a "9+0" axoneme that distinguishes this ancient organelle from the canonical motile "9+2" cilium. A primary cilium is the sensory center of the cell that regulates cell proliferation and embryonic development. The primary ciliary pocket is a specialized endocytic membrane domain in the basal region. The basal body of a primary cilium exists as a form of the centriole during interphase of the cell cycle. Although conventional thinking suggests that the cell cycle regulates centrosomal changes, recent studies suggest the opposite, that is, centrosomal changes regulate the cell cycle. In this regard, centrosomal kinase Aurora kinase A (AurA), Polo-like kinase 1 (Plk1), and NIMA related Kinase (Nek or Nrk) propel cell cycle progression by promoting primary cilia disassembly which indicates a non-mitotic function. However, the persistence of primary cilia during spermatocyte division challenges the dominate idea of the incompatibility of primary cilia and cell division. In this review, we demonstrate the detailed structure of primary cilia and discuss the relationship between primary cilia disassembly and cell cycle progression on the background of various mitotic kinases.

KEYWORDS:

AurA; Ciliogenesis; Nek; Plk1; Primary cilia

PMID:
24971504
DOI:
10.1016/j.gene.2014.06.050
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center