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Braz Dent Sci. 2014;17(1):11-15.

Randomized, double-blind, placebo-controlled clinical trial on the effects of propolis and chlorhexidine mouthrinses on gingivitis.

Author information

1
Biomaterials Research Group School of Dentistry UNIBAN Bandeirante Anhanguera University São Paulo SP Brazil.
2
Professional Masters Program in Pharmacy School of Pharmacy UNIBAN Bandeirante Anhanguera University São Paulo SP Brazil.

Abstract

OBJECTIVE:

The aim of this study was to compare the effects of typified propolis and chlorhexidine mouthrinses on gingival health in a randomized double-blind placebo-controlled clinical trial.

MATERIAL AND METHODS:

Sixty participants were randomized to 3 mouthrinse study groups: 1) 2% typified propolis (n = 20); 2) 0.12% chlorhexidine (n = 20), and 3) placebo (n = 20). Participants rinsed unsupervised twice a day for 28 days. The Papillary Bleeding Score (PBS) was measured on the mesio-buccal surfaces of all teeth at baseline and 28 days thereafter. Co-variance analysis was employed to compare PBS average values and the number of sites with PBS ≥ 2 among study groups. Sub-group analysis was further applied to participants who were < 40 years-old.

RESULTS:

The results show efficacy of propolis mouthrinse when comparing before and after treatment protocols significantly for a reduction of mean PBS scores. For younger participants propolis mouthrinse was superior to all groups in reducing mean PBS scores and significant when compared to 0.12% chlorhexidine mouthrinse.

CONCLUSION:

The efficacy of 2% typified propolis mouthrinse was demonstrated in reducing the levels of gingival inflammation. These results need to be duplicated by other investigators under similar study protocols.

KEYWORDS:

Chlorhexidine; Gingivitis; Propolis

PMID:
24971228
PMCID:
PMC4067770

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