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Lupus. 2014 Oct;23(11):1099-104. doi: 10.1177/0961203314541691. Epub 2014 Jun 26.

Neurodevelopmental disorders in children born to mothers with systemic lupus erythematosus.

Author information

1
Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Canada Division of Rheumatology, McGill University Health Centre, Montreal, Canada evelyne.vinet@mail.mcgill.ca.
2
Division of Rheumatology, McGill University Health Centre, Montreal, Canada.
3
Division of Rheumatology, University of Calgary, Calgary, Canada.
4
Department of Psychiatry, Oregon Health & Sciences University, Portland, OR, USA.
5
Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Canada.
6
Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Canada Division of Rheumatology, McGill University Health Centre, Montreal, Canada.

Abstract

Children born to women with systemic lupus erythematosus seem to have a potentially increased risk of neurodevelopmental disorders compared to children born to healthy women. Recent experimental data suggest in utero exposure to maternal antibodies and cytokines as important risk factors for neurodevelopmental disorders. Interestingly, women with systemic lupus erythematosus display high levels of autoantibodies and cytokines, which have been shown, in animal models, to alter fetal brain development and induce behavioral anomalies in offspring. Furthermore, subjects with systemic lupus erythematosus and neurodevelopmental disorders share a common genetic predisposition, which could impair the fetal immune response to in utero immunologic insults. Moreover, systemic lupus erythematosus pregnancies are at increased risk of adverse obstetrical outcomes and medication exposures, which have been implicated as potential risk factors for neurodevelopmental disorders. In this article, we review the current state of knowledge on neurodevelopmental disorders and their potential determinants in systemic lupus erythematosus offspring.

KEYWORDS:

Systemic lupus erythematosus; neurodevelopmental disorders; pregnancy

PMID:
24969080
DOI:
10.1177/0961203314541691
[Indexed for MEDLINE]
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