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Chem Commun (Camb). 2014 Aug 14;50(63):8768-70. doi: 10.1039/c4cc01610f. Epub 2014 Jun 26.

Enantioselective phospha-Michael addition of diarylphosphines to β,γ-unsaturated α-ketoesters and amides.

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1
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore. pakhing@ntu.edu.sg.

Abstract

An enantioselective hydrophosphination of β,γ-unsaturated α-ketoesters and amides has been developed using a chiral palladacycle catalyst. Adducts can be obtained in excellent yields and enantioselectivities, providing direct access to chiral tertiary phosphines which are synthetically useful intermediates in the preparation of bidentate ligands.

PMID:
24968261
DOI:
10.1039/c4cc01610f
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