Format

Send to

Choose Destination
See comment in PubMed Commons below
Biomed Res Int. 2014;2014:426710. doi: 10.1155/2014/426710. Epub 2014 May 20.

Effect of nonviral plasmid delivered basic fibroblast growth factor and low intensity pulsed ultrasound on mandibular condylar growth: a preliminary study.

Author information

1
Department of Dentistry, Faculty of Medicine and Dentistry, Medical Science Graduate Program, University of Alberta, Edmonton, AB, Canada T6G 2E1.
2
Department of Chemical and Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, AB, Canada T6G 2E1.
3
Department of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2E1.

Abstract

OBJECTIVE:

Basic fibroblast growth factor (bFGF) is an important regulator of tissue growth. Previous studies have shown that low intensity pulsed ultrasound (LIPUS) stimulates bone growth. The objective of this study was to evaluate the possible synergetic effect of LIPUS and local injection of nonviral bFGF plasmid DNA (pDNA) on mandibular growth in rats.

DESIGN:

Groups were control, blank pDNA, bFGF pDNA, LIPUS, and bFGF pDNA + LIPUS. Treatments were performed for 28 days. Significant increase was observed in mandibular height and condylar length in LIPUS groups. MicroCT analysis showed significant increase in bone volume fraction in bFGF pDNA + LIPUS group. Histomorphometric analysis showed increased cell count and condylar proliferative and hypertrophic layers widths in bFGF pDNA group.

RESULTS:

Current study showed increased mandibular condylar growth in either bFGF pDNA or LIPUS groups compared to the combined group that showed only increased bone volume fraction.

CONCLUSION:

It appears that there is an additive effect of bFGF + LIPUS on the mandibular growth.

PMID:
24967367
PMCID:
PMC4055166
DOI:
10.1155/2014/426710
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Support Center