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Int J Nephrol Renovasc Dis. 2014 Jun 9;7:219-30. doi: 10.2147/IJNRD.S42054. eCollection 2014.

Hypomagnesemia: a clinical perspective.

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Olive View-UCLA Medical Center, Los Angeles, CA, USA.
Veterans Administration Central California Health Care System, Fresno, CA, USA.
South Texas Veterans Health Care System and University of Texas Health Science Center, San Antonio, TX, USA.
Pennsylvania State University Wilkes-Barre, Lehman, PA, USA.
Greater Los Angeles Veterans Administration, Sepulveda, CA, USA.
David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.


Although magnesium is involved in a wide spectrum of vital functions in normal human physiology, the significance of hypomagnesemia and necessity for its treatment are under-recognized and underappreciated in clinical practice. In the current review, we first present an overview of the clinical significance of hypomagnesemia and normal magnesium metabolism, with a focus on renal magnesium handling. Subsequently, we review the literature for both congenital and acquired hypomagnesemic conditions that affect the various steps in normal magnesium metabolism. Finally, we present an approach to the routine evaluation and suggested management of hypomagnesemia.


TRPM6; alcohol; cisplatin; diabetes mellitus; hypomagnesemia; magnesium

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